By Michael Hirsch, Allan Tucker, Stephen Swift, Nigel Martin, Christine Orengo (auth.), Michael R. Berthold, Robert C. Glen, Ingrid Fischer (eds.)
This booklet constitutes the refereed lawsuits of the second one overseas Symposium on Computational existence Sciences, CompLife 2006, held in Cambridge, united kingdom, in September 2006.
The 25 revised complete papers awarded have been rigorously reviewed and chosen from fifty six preliminary submissions. The papers are geared up in topical sections on genomics, info mining, molecular simulation, molecular informatics, platforms biology, organic networks/metabolism, and computational neuroscience.
Read or Download Computational Life Sciences II: Second International Symposium, CompLife 2006, Cambridge, UK, September 27-29, 2006. Proceedings PDF
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Extra resources for Computational Life Sciences II: Second International Symposium, CompLife 2006, Cambridge, UK, September 27-29, 2006. Proceedings
1) where d is the number of the leading eigenvalues. 1). Therefore, we group the leading two eigenvalues to reconstruct the expression profiles . 2. Parametric Spectral Analysis of Malaria Gene Expression Time Series Data 35 250 Eigenvalue 200 150 100 50 0 0 5 10 15 20 25 Mode Fig. 1. The eigenvalue spectra of Dihydrofolate Reductase-Thymidylate Synthase (DHFS-TS). The spectra contains a steep slope. The leading two eigenvalues which contain most energy represent the signal, and a “flat floor”, representing the noise level.
4496 genes which expressed periodically are ordered along the y axis in the order of the time of their peak expression for the convenience of gene function classification. The different developmental stages throughout the IDC are shown on the left. The phaseogram reveals a continuous cascade of gene expression. Merozoite invasion is one of the most promising target areas for antimalarial vaccine developpment. Among these invasion proteins are seven of the well known malaria vaccine candidates, including Apical Merozite Antigen-1 (AMA1), Merozoite Surface Protein-1 (MSP1), Merozoite Surface Protein-3 (MSP3), Merozoite Surface Protein-5 (MSP5), Erythrocyte Binding Antigen-175 (EBA175), Rhoptry-Associated Protein-1 (RAP1) and Ring-infected Erythrocyte Surface Antigen-1 (RESA1).
6 are considered to be reconstructed. Secondly, the AR spectrum is calculated for each reconstructed expression profiles. Then the frequency f m at peak value point and the ratio of the power in f m ’s influencing region to the total power are calculated according to Equation (4). 7 (which is the same value as that used in ), the corresponding profile would be selected for further processing, otherwise, we consider it lacking of periodicity and discard it. 1 Statistical Significance We have tested our algorithm on the expression data of the IDC of P.
Computational Life Sciences II: Second International Symposium, CompLife 2006, Cambridge, UK, September 27-29, 2006. Proceedings by Michael Hirsch, Allan Tucker, Stephen Swift, Nigel Martin, Christine Orengo (auth.), Michael R. Berthold, Robert C. Glen, Ingrid Fischer (eds.)