Download e-book for kindle: Computational Genome Analysis by Deonier R.C., Waterman M.S., Tavaré S.

By Deonier R.C., Waterman M.S., Tavaré S.

ISBN-10: 0387987851

ISBN-13: 9780387987859

Computational Genome research: An advent offers the rules of key difficulties in computational molecular biology and bioinformatics. It makes a speciality of computational and statistical rules utilized to genomes, and introduces the math and facts which are an important for figuring out those functions. The booklet is acceptable for a one-semester path for complex undergraduate or starting graduate scholars, and it may possibly additionally introduce computational biology to desktop scientists, mathematicians, or biologists who're extending their pursuits into this fascinating box.

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Example text

In contrast, a DNA segment of similar length in mitochondrial DNA (mtDNA, present at 103 -104 copies/mammalian somatic cell) will be at least a thousand times more abundant. The molecular sizes also matter. A 1000 bp DNA segment of eukaryotic DNA from a particular chromosome is part of a long, linear DNA molecule that cannot be easily purified without fragmentation, which destroys long-distance relationships to other regions of the molecule. In contrast, a similar length segment in mitochondrial DNA can be easily purified on an intact molecule because the mtDNA molecules are small, circular molecules that can be purified without fragmentation.

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Proteins are polypeptides that may have catalytic, structural, or regulatory roles. 1 DNA The genomes of free-living (nonviral) organisms are composed of DNA. The subunits (nucleotides) of these macromolecules are deoxyribonucleotides of four types: deoxyadenosine 5 -phosphate (A), deoxycytidine 5 -phosphate (C), deoxyguanosine 5 -phosphate (G), and thymidine 5 -phosphate (T). The 5 position on the sugar of each nucleotide is connected via a phosphate group to the 3 position on the sugar of the immediately preceding nucleotide.

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Computational Genome Analysis by Deonier R.C., Waterman M.S., Tavaré S.

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