By Nicole Jung, Matthias Wiehn, Stefan Bräse (auth.), Stefan Bräse (eds.)
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"This e-book, written via a world workforce of popular specialists of their respective box, covers contemporary advances in very important issues relating to combinatorial chemistry on strong helps. … it will likely be an invaluable addition to the evaluate literature and may be of curiosity to an important phase of fellow workers operating in SPOC." (Rolando Perez-Pineiro and Hicham Fenniri, JACS, Vol. one hundred thirty (13), 2008)
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Additional resources for Combinatorial Chemistry on Solid Supports
The ingenious undemanding Hartwig–Buchwald palladium-catalyzed carbon-nitrogen coupling can also be favorably used for the synthesis of benzotriazoles (332). This way, both the amine and the arylhalide can be immobilized. Crucial for the success is the careful choice of the ligand used (Scheme 47). Other heterocyclic systems that can be prepared include cinnolines 338 which are available from o-alkynylaryl or o-alkynylaryl triazenes via a cleavage-cyclization strategy. Starting with the immobilization of diverse 38 N.
There exist, for example, procedures for photolabile linkers, linkers that are thermally cleavable and linkers that release target structures upon addition of hydrogenating reagents. Linkers for these methodologies are of a different nature as a result of their need to fulﬁl special demands. Cleavage products from thioether linkers do not only depend on the nature of the linker and the cleavage procedure. Even slight differences concerning the loaded substrate itself can have an inﬂuence on the cleavage result as 46 N.
The latter ones are accessible from carboxylate resins and amines by peptide coupling methods. Multifunctional Linkers for Combinatorial Solid Phase Synthesis 39 Another multifunctional cleavage of the T1 linker is based on concept III which uses the ﬂexibility of the azide functionality. Upon thermolysis or photolysis, appropriately substituted aryl azides lose nitrogen gas to give intermediate nitrenes, which in turn cyclize with suitable ortho-substituents to give benzoannelated heterocycles.
Combinatorial Chemistry on Solid Supports by Nicole Jung, Matthias Wiehn, Stefan Bräse (auth.), Stefan Bräse (eds.)