Download e-book for iPad: Clinical trials in neurology : design, conduct, analysis by Bernard Ravina; et al

By Bernard Ravina; et al

ISBN-10: 1139032445

ISBN-13: 9781139032445

ISBN-10: 1139379445

ISBN-13: 9781139379441

''Translating laboratory discoveries into winning therapeutics should be tricky. scientific Trials in Neurology goals to enhance the potency of medical trials and the improvement of interventions so that it will increase the improvement of latest remedies for neurologic ailments. It introduces the reader to the main options underpinning trials within the neurosciences. This quantity tackles the demanding situations of developing Read more...

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13. Ghersi-Egea JF, Leininger-Muller B, Cecchelli R, and Fenstermacher JD. Blood-brain interfaces: relevance to cerebral drug metabolism. Toxicol Lett 1995; 82–83: 645–53. 14. Terasaki T and Ohtsuki S. Brain-to-blood transporters for endogenous substrates and xenobiotics at the bloodbrain barrier: an overview of biology and methodology. NeuroRx 2005; 2: 63–72. 15. Loscher W and Potschka H. Blood-brain barrier active elux transporters: ATP-binding cassette gene family. NeuroRx 2005; 2: 86–98. 16.

For example, initial eicacy trials in middle stage may uncover that peripheral edema complicates the use of a medication in a signiicant percentage of patients. For any patient presenting with a complaint of edema, speciic additional medical history is recorded, limb measures are taken and additional blood, urine or other testing is performed to more fully understand the nature of the edema in speciic cases. At the end of the late stage program, these data are summarized and described in aggregate and can provide signiicant insight into a particular safety or tolerability issue.

In addition, diiculties arise because of the complexity of the CNS and the challenges of developing clinical endpoints to capture therapeutic efects on multiple functional domains controlled by complex brain Chapter 3: Unique challenges in the development of therapies circuits. Some of these problems have arisen because we have historically used clinical scales that were developed to describe subgroups of domains afected by CNS diseases. One example is the EDSS in MS which is largely inluenced by lower extremity walking function, but less so by cognition or upper extremity function.

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Clinical trials in neurology : design, conduct, analysis by Bernard Ravina; et al


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