By Pankaj Jay Pasricha, William D. Willis, G. F. Gebhart
Status by myself because the first definitive and complete booklet at the topic, this consultant describes the newest experiences at the brain-gut connection and psychosocial matters regarding sufferers experiencing visceral discomfort. Bringing jointly top specialists from the top-tiers of the technological know-how, this resource offers 33 attractive chapters and spans uncomplicated thoughts in pharmacology, neurobiology, body structure, and psychology to supply a realistic method of the remedy of persistent ache.
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Extra resources for Chronic Abdominal and Visceral Pain: Theory and Practice
15. Talley NJ et al. Medical costs in community subjects with irritable bowel syndrome. Gastroenterology 1995; 109(6):1736. 16. Agreus L et al. Irritable bowel syndrome and dyspepsia in the general population: overlap and lack of stability over time. Gastroenterology 1995; 109:671. 17. Rodriquez LG et al. Detection of colorectal tumor and inflammatory bowel disease during follow-up of patients with initial diagnosis of irritable bowel syndrome. Scand J Gastroenterol 2000; 35:306. 18. Locke GRI et al.
The incidence of a clinical diagnosis of IBS has been estimated to be 196 to 260 per 100,000 person-years (17,18). This is not the true incidence of IBS but rather the rate at which the diagnosis of IBS is made in the clinic. These numbers may seem low; however, when multiplied by 30 years of disease duration and then doubled to reflect the rate of those seeking health care, the result is 12%, which matches the prevalence reported in the symptom surveys. It is noteworthy that these incidence rates are also much higher than the rates reported for colorectal cancer and inflammatory bowel disease, which are 50 and 10 per 100,000 person-years, respectively (19,20).
The a-subunit contains the voltage sensor and ion channel. Nine a-subunits have been identified, which differ with respect to their pharmacological sensitivity and biophysical properties. Phosphorylation of VGSC a-subunits results in changes in biophysical properties of the channel (71). b-subunits also influence the biophysical properties of VGSCs and are instrumental in targeting VGSCs to specific sites in the cell membrane (72). Thus, there are a number of ways in which changes in VGSCs may contribute to the sensitization of nociceptive afferents in the presence of tissue injury or disease.
Chronic Abdominal and Visceral Pain: Theory and Practice by Pankaj Jay Pasricha, William D. Willis, G. F. Gebhart