New PDF release: Botulinum Toxin. Therapeutic Clinical Practice and Science

By Joseph Jankovic MD, Alberto Albanese, M. Zouhair Atassi PhD DSc, J. Oliver Dolly, Mark Hallett, Nathaniel H. Mayer

ISBN-10: 1416049282

ISBN-13: 9781416049289

The recent, therapeutically-focused Botulinum Toxin provides entire, cross-disciplinary suggestions on present practices, protecting greater than a hundred non-cosmetic stipulations that take place in neurology, actual drugs and rehabilitation, soreness drugs, ophthalmology, gastroenterology, urology, orthopedics, and surgical procedure. overseas members assessment the present realizing of the biology and mobile mechanisms Read more...

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Additional info for Botulinum Toxin. Therapeutic Clinical Practice and Science

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In addition to the similarity in fold, there are other remarkable similarities that suggest that the catalytic mechanism of all these serotypes is similar. About 40 to 45 residues are present within a sphere of radius of 10 A˚ centered on the zinc atom. A few interactions are common to all of them, and they all involve conserved residues across serotypes (Fig. 2-8). The sequence numbers corresponding to BoNT/E are used in the FIGURE 2-7. The catalytic domain of BoNT/E shown in ribbons representation.

The helical fragment of Syt II from Chai et al. 27 The helical fragment occupies the same place as the tripeptide in tetanus. This strongly supports our earlier prediction that site 2 may be the site where the receptor protein would bind. FIGURE 26. Doxorubicin binding in site 1 of BoNT/B. Sialyllactose, a mimic of GT1b, binds in the same site. Also, doxorubicin has been shown to compete with gangliosides for binding to this site. 1-7 However, the mechanism underlying the translocation of the endocytosed protease from acidic endosomes into the cytosol is poorly understood.

Biochemistry. 1996;35:2630-2636. 49. Sollner T, Whiteheart SW, Brunner M, ErdjumentBromage H, Geromanos S, Tempst P, et al. SNAP receptors implicated in vesicle targeting and fusion. Nature. 1993;362:318-324. 50. Schiavo G, Rossetto O, Santucci A, Dasgupta BR, Montecucco C. Botulinum neurotoxins are zinc proteins. J Biol Chem. 1992;267:23479-27483. 51. Schiavo G, Poulain B, Rossetto O, Benfenati F, Tauc L, Montecucco C. Tetanus toxin is a zinc protein and its inhibition of neurotransmitter release and protease activity depend on zinc.

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Botulinum Toxin. Therapeutic Clinical Practice and Science by Joseph Jankovic MD, Alberto Albanese, M. Zouhair Atassi PhD DSc, J. Oliver Dolly, Mark Hallett, Nathaniel H. Mayer


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