W.P. Kaschka, D. Rujescu, W.F. Gattaz's Biological Aspects of Suicidal Behavior PDF

By W.P. Kaschka, D. Rujescu, W.F. Gattaz

ISBN-10: 3318055832

ISBN-13: 9783318055832

Suicide is without doubt one of the most vital motives of dying in smooth societies. To improve more desirable preventive measures, we need to concentrate on and examine extra approximately its neurobiological foundations. in recent times, the instruments of contemporary neurosciences have more and more been applied to represent the pathophysiology of advanced human behaviors reminiscent of suicide. to enhance suicide possibility evaluate and suicide prevention, a greater figuring out of its pathophysiology is important. This contains study from numerous disciplines equivalent to neuropsychological, psychosocial and cultural stories but additionally findings from biochemistry, neuropathology, electrophysiology, immunology, neuroimaging, genetics, and epigenetics. vital effects have, for instance, been bought within the box of gene-environment interplay and suicidal habit. we have now simply all started to appreciate how early-life adversity may possibly bring up suicide danger through epigenetic mechanisms. in accordance with such insights, novel healing interventions and preventive measures will be constructed. additionally, a greater realizing of the pathophysiological mechanisms serious about suicidal habit may well show the mechanism of compounds like lithium salts. during this ebook, suicidal habit and its prevention is mentioned by way of overseas specialists within the mild of the latest effects from a extensive spectrum of neurosciences.

Show description

Read or Download Biological Aspects of Suicidal Behavior PDF

Best neurology books

Oliver G. Cameron M.D. Ph.D., W.D. Hamilton, Jonathan's Visceral Sensory Neuroscience: Interoception PDF

It's been recognized for over a century that there's an afferent(body-to-brain), in addition to an efferent(brain-to-body), part of the visceral-atonomic worried procedure. regardless of the basic value of physically afferent details- often referred to as interoception- to relevant fearful procedure keep an eye on of visceral organ functionality, emotional-motivational techniques, and disorder of those techniques, together with psychosomatic issues, its position didn't obtain a lot cognizance till really lately.

Download PDF by O. Joseph Bienvenu, Lisa A. Wuyek (auth.), Murray B. Stein,: Behavioral Neurobiology of Anxiety and Its Treatment

The publication is a part of a chain on present themes in Behavioral Neurosciences, which has as its concentration anxiousness and its therapy. now we have introduced jointly a unusual cadre of authors with the purpose of overlaying a wide array of themes regarding nervousness issues, starting from scientific prognosis, epidemiology, preclinical neuroscience, and animal types to confirmed and cutting edge healing methods.

Multiple Sclerosis : Recovery of Function and by Jürg Kesselring, Giancarlo Comi, Alan J. Thompson PDF

Contemporary advancements in uncomplicated and utilized technological know-how have ended in greater knowing of illness mechanisms and extra effective cures for a number of sclerosis. the simplest approach of coping with those sufferers is thru a delicately deliberate neurorehabilitation programme. the most goals are to lessen incapacity and handicap and increase services via potent education, stimulating task and social participation.

Extra resources for Biological Aspects of Suicidal Behavior

Sample text

19 Wasserman D, Wasserman J, Sokolowski M: Genetics of HPA-axis, depression and suicidality. Eur Psychiatry 2010;25: 278–280. 20 Sarchiapone M, D’Aulerio M: Genetic risk factors for suicidal behavior; in Cannon KE, Hudzik TJ (eds): Suicide: Phenomenology and Neurobiology. New York, Springer, 2014, pp 125–140. 21 Pandey GN, Rizavi HS, Ren X, Dwivedi Y, Palkovits M: Region-specific alterations in glucocorticoid receptor expression in the postmortem brain of teenage suicide victims. Psychoneuroendocrinology 2013;38:2628–2639.

Adv Biol Psychiatry. 1159/000435768) MARCKS was increased in depressed suicide subjects but was decreased in nondepressed suicides. Interestingly, PKC-mediated phosphorylation of MARCKS was lower in the PFC of both depressed and nondepressed suicides. It appears that the PKCmediated functional response at the level of MARCKS is abnormal in suicide subjects regardless of its expression level. Protein Kinase A in Suicide In the adenylyl cyclase-cAMP pathway, the effects of cAMP are primarily mediated by its receptor PKA.

19], who used 3 H-ketanserin as radioligand, did not find any significant differences in the PFC between suicide victims and normal control subjects. Subsequently, several studies examined 5-HT2A receptors in postmortem brains of suicide victims and found them to be increased primarily in the PFC [20–23]. A few studies did not find any significant differences [24, 25]. On the other hand, one study found a decrease in ketanserin binding in the PFC of suicide victims [26] and two studies found a decrease in the Neurotransmitter System and Suicide Kaschka WP, Rujescu D (eds): Biological Aspects of Suicidal Behavior.

Download PDF sample

Biological Aspects of Suicidal Behavior by W.P. Kaschka, D. Rujescu, W.F. Gattaz

by James

Rated 4.86 of 5 – based on 44 votes