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B ∗1 x:Γ P1 B ∗2 B ∗1 y:∆ P2 −→ x:Γ P1 | P2 {x/y } Such a reduction, in a formal context where nesting of boxes is intentionally avoided, can be used to render biological endocytosis, namely the absorbtion of substances from the external environment. Indeed, the pi-component of the absorbed box (P2 ) is moved into the absorbing bio-process, and the engulfed material has no longer a proper beta binder to interact with the external world. The specific instance of fjoin defined in (4) assumes that the endocytosis reduction can take place only if absorbing and absorbed bio-process have complementary sites (elementary beta binders with non disjoint types), and also states that the absorbed process can keep interacting with the external environment through the same site which has been used to absorb it (σ2 = {x/y }).

Relative to SB the SA have a shorter path length and a smaller surface-to-volume ratio, whereas the SB have a longer path length and a larger surface-to-volume ratio. The circumference of each SS is specified by a random draw from a bounded uniform distribution. To reflect the observed relative range of real sinusoid path lengths, SS length is given by a random draw from a gamma distribution having a mean and variance specified by the three gamma function parameters, α, β, and γ. Solute objects can enter a SS at either the Core or the Rim.

Fr Abstract. We present a multi-site model describing the alternative use of the RNA splicing sites A3, A4, A5 and A7 in the human immunodeficiency virus HIV-1. Our goal is to integrate experimental data obtained on individual splicing sites into a global model of HIV-1 RNA alternative splicing. We give a qualitative validation of our model, and analyse the possible impact of variations of regulatory protein concentrations on virus multiplication. 1 Introduction The life cycle of the human immunodeficiency virus HIV-1 involves the production of different kinds of proteins.

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Advanced scientific computing (B673) by Meglicki Z.

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