New PDF release: Acute Neuronal Injury: The Role of Excitotoxic Programmed

ISBN-10: 038773225X

ISBN-13: 9780387732251

Denson G. Fujikawa 2+ within the early Nineteen Eighties it was once well-known that over the top Ca inflow, possibly via 2+ 2+ voltage-gated Ca channels, with a resultant raise in intracellular Ca, was once linked to neuronal loss of life from cerebral ischemia, hypoglycemia, and standing epilepticus (Siejo 1981). Calcium activation of phospholipases, with arachidonic acid accumulation and its oxidation, producing loose radicals, used to be considered a possible mechanism during which neuronal harm happens. In cerebral ischemia and a couple of+ hypoglycemia, strength failure used to be regarded as the cause of over the top Ca inflow, while in prestige epilepticus it was once concept that repetitive depolarizations have been dependable (Siejo 1981). in the meantime, John Olney chanced on that monosodium glutamate, the nutrition additive, while given to immature rats, used to be linked to neuronal degeneration within the arcuate nucleus of the hypothalamus, which lacks a blood-brain barrier (Olney 1969). He up this remark with a sequence of observations within the Nineteen Seventies that management of kainic acid, which we now understand prompts the GluR5-7 subtypes of glutamate receptor, and different glutamate analogues, triggered not just post-synaptic cytoplasmic swelling, but additionally dark-cell degeneration of neurons, whilst considered by means of electron microscopy (Olney 1971; Olney et al. 1974).

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Cmd=Retrieve&db=pubmed&dopt=A bstract&list_uids=8504896 • Successful treatment of adult Arnold-Chiari malformation associated with basilar impression and syringomyelia by the transoral anterior approach. Author(s): Kohno K, Sakaki S, Shiraishi T, Matsuoka K, Okamura H. Source: Surgical Neurology. 1990 April; 33(4): 284-7. cmd=Retrieve&db=pubmed&dopt=A bstract&list_uids=2326735 • Sudden respiratory arrest and Arnold-Chiari malformation. Author(s): Yoshikawa H. Source: European Journal of Paediatric Neurology : Ejpn : Official Journal of the European Paediatric Neurology Society.

0378-4274 Federal Resources on Nutrition In addition to the IBIDS, the United States Department of Health and Human Services (HHS) and the United States Department of Agriculture (USDA) provide many sources of information on general nutrition and health. gov/fns/ Additional Web Resources A number of additional Web sites offer encyclopedic information covering food and nutrition. html 31 33 CHAPTER 3. ALTERNATIVE MEDICINE AND ARNOLDCHIARI MALFORMATION Overview In this chapter, we will begin by introducing you to official information sources on complementary and alternative medicine (CAM) relating to Arnold-Chiari malformation.

Cmd=Retrieve&db=pubmed&dopt=A bstract&list_uids=660206 • Surgical treatment of hydrocephalus caused by Arnold-Chiari malformation in infants and young children. Author(s): Crosby RM, Paul RL, Kosnik EJ. Source: The American Surgeon. 1972 July; 38(7): 377-9. cmd=Retrieve&db=pubmed&dopt=A bstract&list_uids=5033762 • Symptomatic Arnold-Chiari malformation: review of experience with 22 cases. Author(s): Bell WO, Charney EB, Bruce DA, Sutton LN, Schut L. Source: Journal of Neurosurgery. 1987 June; 66(6): 812-6.

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Acute Neuronal Injury: The Role of Excitotoxic Programmed Cell Death Mechanisms


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