By National Research Council, Board on Environmental Studies and Toxicology, Committee on Toxicology, Committee on Acute Exposure Guideline Levels
This ebook is the 6th quantity within the sequence Acute publicity instruction degrees for Selected Airborne Chemicals, and comprises AEGLs for chemical substances comparable to ammonia, nickel carbonyl and phosphine, between others.
At the request of the dept of security, the nationwide examine Council has reviewed the proper clinical literature compiled through a professional panel and confirmed Acute publicity instruction degrees (AEGLs) for 12 new chemical substances. AEGLs signify publicity degrees under which opposed future health results will not be prone to take place and are worthwhile in responding to emergencies similar to unintended or intentional chemical releases locally, the place of work, transportation, the army, and for the remediation of infected sites.
Three AEGLs are authorized for every chemical, representing publicity degrees that lead to: 1) awesome yet reversible ache; 2) long-lasting health and wellbeing results; and three) life-threatening well-being impacts.
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Additional info for Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 6
The lesions were shown to be dependent on the metabolism of allylamine by SSAO, of which tissue levels were greatest in the aorta and coronary arteries (Lewinsohn et al. 1978; Conklin et al. 2001; Boor and Hysmith 1987; Lyles 1996). SSAO specificity for allylamine as a substrate has not been determined, and Lyles (1996) has shown that substrate specificity of plasma and tissue SSAO varied considerably among species for a number of aromatic and aliphatic amines. Inhalation exposure was also capable of inducing cardiovascular lesions, although this was shown only in rats.
Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 6 35 Allylamine The Guzman et al. 1 ppm for the 1-h AEGL-2. The same value would be appropriate for 10 and 30 min because scaling from 16 h to <1 h involves unacceptably high inherent uncertainty (analogous to scaling from ≥4 h to 10 min) and the 1-h value would be adopted to be protective of human health. However, the human irritation study (Hine et al. 3 ppm for 10-60 min, providing a more sensitive end point for this time period than the rat cardiotoxicity study.
3 ppm (Gagnaire et al. 1993). Mice were exposed by enclosing the head in a 200-L stainless steel exposure chamber into which allylamine vapor was delivered by bubbling air through the liquid amine. The effect on breathing rate was maximal 10-15 min after exposure in both studies; recovery after the 15-min exposure occurred within 1 min; recovery after the 60-min exposure was slower. Pulmonary toxicity was analogously assessed in anesthetized, tracheally cannulated (TC) mice exposed to 38, 59, 79, or 205 ppm of allylamine for 120 min and an RD50TC of 157 ppm was determined (RD50TC is the concentration of allylamine causing a 50% decrease in the breathing rate of tracheally cannulated mice; Gagnaire et al.
Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 6 by National Research Council, Board on Environmental Studies and Toxicology, Committee on Toxicology, Committee on Acute Exposure Guideline Levels