By National Research Council, Division on Engineering and Physical Sciences, Board on Environmental Studies and Toxicology, Committee on Toxicology, Subcommittee on Acute Exposure Guideline Levels
Super dangerous elements (EHSs)² could be published by accident due to chemical spills, commercial explosions, fires, or injuries regarding railroad vehicles and vans transporting EHSs. staff and citizens in groups surrounding business amenities the place EHSs are synthetic, used, or kept and in groups alongside the nation's railways and highways are possibly vulnerable to being uncovered to airborne EHSs in the course of unintentional releases or intentional releases via terrorists. Pursuant to the Superfund Amendments and Reauthorization Act of 1986, the U.S. Environmental security enterprise (EPA) has pointed out nearly four hundred EHSs at the foundation of acute lethality info in rodents. As a part of its efforts to strengthen acute publicity instruction degrees for EHSs, EPA and the organisation for poisonous ingredients and sickness Registry (ATSDR) in 1991 asked that the nationwide examine Council (NRC) boost instructions for constructing such degrees. in keeping with that request, the NRC released guidance for constructing neighborhood Emergency publicity degrees for dangerous ingredients in 1993. as a consequence, usual working strategies for constructing Acute publicity instruction degrees for damaging ingredients was once released in 2001, delivering up to date strategies, methodologies, and different directions utilized by the nationwide Advisory Committee (NAC) on Acute publicity guide degrees for harmful components and the Committee on Acute publicity guide degrees (AEGLs) in constructing the AEGL values. In 1998, EPA and DOD asked that the NRC independently evaluation the AEGLs built by way of NAC. according to that request, the NRC geared up inside its Committee on Toxicology (COT) the Committee on Acute publicity guide degrees, which ready this file. Acute publicity instruction degrees for chosen Airborne chemical substances is the 10th quantity of the sequence and files for N,N-dimethylformamide, jet propellant fuels five and eight, methyl ethyl ketone, perchloromethyl mercaptan, phosphorus oxychloride, phosphorus trichloride, and sulfuryl chloride.
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Extra resources for Acute Exposure Guideline Levels for Selected Airborne Chemicals
In the 13week exposure study, body weight was reduced in male and female rats exposed to DMF at 400 and 800 ppm, and feed consumption was reduced in rats exposed at 800 ppm. Relative liver weight was increased in male rats exposed at ≥100 ppm and in female rats exposed at ≥200 ppm. Histopathologic examination revealed increased hepatic single-cell necrosis in male and female rats exposed at ≥200 ppm and in centrilobular hypertrophy in male and female rats exposed at ≥400 ppm. Clinical chemistry analyses revealed increased ALT, AST, lactate dehydrogenase (LDH), GGT, total cholesterol, and phospholipid in male and female rats (generally occurring in males exposed at ≥50 ppm and females exposed at ≥200 ppm).
8% vs. 43% for controls), but the increase did not attain statistical significance. An increased litter incidence of aplasia of some sternebrae was observed in exposed fetuses from both Groups I and II (Group 1: 12/18 vs. 3/19 for controls; Group II: 11/17 vs. 5/20 for controls). No treatment-related adverse effects were observed in dams or pups that were allowed to deliver their offspring. Groups of 22 or 23 impregnated Long Evans rats inhaled DMF at measured concentrations of DMF at 0, 18, or 172 ppm dissolved in polyethylene glycol 400 (20 mm3/L air) for 6 h/day during GD 6-15 (Kimmerle and Machemer 1975).
47 to 100 ppm. DMF is a polar compound used as a solvent in the manufacturing of many products. American manufacturers consumed 32 million pounds of DMF in 1993 (TURI 2001). The primary end-users of DMF are manufacturers of pharmaceuticals (12 million pounds), electronic components (10 million pounds), butadiene (3 million pounds), and urethanes (3 million pounds). It is also used as a resin cleanup solvent, reaction solvent, and processing solvent in the manufacture of polyimides, optical brightners, semipermeable membranes, and pesticides.
Acute Exposure Guideline Levels for Selected Airborne Chemicals by National Research Council, Division on Engineering and Physical Sciences, Board on Environmental Studies and Toxicology, Committee on Toxicology, Subcommittee on Acute Exposure Guideline Levels